The diagnostic value of exosomal circular RNAs in cancer patients: A systematic review and meta-analysis.

ABSTRACT:

Background

Recently, serum exosomal circular RNAs (circRNAs) were applied to discriminate cancer patients from healthy individuals, indicating that exosomal circRNAs have the potential to be novel biomarkers for cancer diagnosis. This study aims to summarize the role of exosomal circRNAs in cancer diagnosis by a meta-analysis.

Methods

A comprehensive literature search was conducted up to July 2021 in PubMed, Web of Science, EMBASE, and Cochrane Database. To evaluate the diagnostic value, the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were pooled. Threshold effect followed by subgroup analysis and meta-regression were performed to explore the source of heterogeneity. S

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9883561 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature