Sociodemographic and clinical factors associated with receipt of biomarker testing in patients with metastatic colorectal cancer.

ABSTRACT:

Background

Standard clinical practice and national guidelines dictate somatic testing of metastatic colorectal cancer (mCRC) tumors to guide appropriate therapy; however, previous studies suggest that not all patients are tested. The objective of this study was to investigate potential differences in testing for mCRC by demographic and clinical factors.

Methods

We performed a retrospective review of de-identified patient data derived from electronic health records (EHRs) of 25,469 patients diagnosed with mCRC between the years 2013 and 2020. Our outcome was a receipt of the following tests: (a) biomarker testing (BRAF, KRAS, NRAS, MMR/MSI) and (b) next-generation sequencing (NGS). We interrogated our data using the machine-learning algorithm Classification and Regression Tre

SUBMITTER: Markt SC 

PROVIDER: S-EPMC9883565 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature