Identification of Ferroptosis-related molecular model and immune subtypes of hepatocellular carcinoma for individual therapy.

ABSTRACT:

Background

Excessive iron accumulation and lipid peroxidation are primary characteristics of ferroptosis in hepatocellular carcinoma (HCC). Ferroptosis inducer combined with immunotherapy has become a new hope for HCC patients. Therefore, the construction and validation of subtype-specific sensitivity to ferroptosis inducer will be helpful for hierarchical management and precise individual therapy.

Methods

RNA-seq transcriptome and clinical data of HCC patients were extracted from International Cancer Genome Consortium (ICGC) dataset and The Cancer Genome Atlas (TCGA) dataset. Consistency matrix and data clustering of the both cohorts were constructed by 'ConsensusClusterPlus' package. Single-sample gene set enrichment analysis (ssGSEA) analysis was performed to evaluate imm

SUBMITTER: Long S 

PROVIDER: S-EPMC9883587 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature