Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis.

ABSTRACT:

Background

Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures.

Objectives

We aimed to investigate somatostatin receptor 2 (SST₂) as a novel inflammation-specific molecular imaging target in LVV.

Methods

In a prospective, observational cohort study, in vivo arterial SST₂ expression was assessed by positron emission tomography/magnetic resonance imaging (PET/MRI) using ⁶⁸Ga-DOTATATE and ¹⁸F-FET-βAG-TOCA. Ex vivo mapping of the imaging target was performed using immunofluorescence microscopy; imaging mass cytometry; and bulk, single-cell, and single-nucleus RNA sequencing.

Results

Sixty-one participants (LVV: n = 27; recent atherosclerotic myocardial infar

SUBMITTER: Corovic A 

PROVIDER: S-EPMC9883634 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature