Physiologically-based pharmacokinetic modeling to predict drug-drug interactions of dabigatran etexilate and rivaroxaban in the Chinese older adults.

ABSTRACT:

Introduction

Drug-drug interaction (DDI) is one of the major concerns for the clinical use of NOACs in the older adults considering that coexistence of multiple diseases and comorbidity were common. Current guidelines on the DDI management were established based on clinical studies conducted in healthy adults and mainly focus on the Caucasians, whereas systemic and ethnic differences may lead to distinct management in the Chinese older adults.

Objectives

To investigate the impact of aging on the DDI magnitude between P-gp and/or CYP3A4 inhibitors with dabigatran etexilate and rivaroxaban in older adults, providing additional information for the use in clinical practice.

Results

Compared with the simulated adult, the AUC of the simulated older adults increased by 42-88

SUBMITTER: Sia JEV 

PROVIDER: S-EPMC9883662 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature