Self-Reported Race as a Social Determinant of Stroke Risk in Observational Versus Clinical Trial Datasets.

ABSTRACT:

Objectives

Self-reported Black (SRB) Americans are approximately twice as likely to have a stroke as self-reported White (SRW) Americans. While social determinants of health and vascular risk factors account for some of the disparity, half the increased risk remains unexplained and may be related to unmeasured real-world factors of the racialized experience.

Materials

and Methods In this cohort study, we compared SRB and SRW participants in the Systolic Blood Pressure Intervention Trial (SPRINT) to the same groups in the observational Atherosclerosis Risk in Communities (ARIC) study to evaluate if clinical trial participation mitigates disparities in stroke risk. We set the ARIC baseline at visit 4 and excluded participants with prior stroke to create an ARIC cohort similar

SUBMITTER: Herman AL 

PROVIDER: S-EPMC9883695 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature