Dendritic cells can prime anti-tumor CD8⁺ T cell responses through major histocompatibility complex cross-dressing.

ABSTRACT: Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by which DCs initiate tumor-specific CD8⁺ T cell responses. Here, we demonstrate that MHC-I cross-dressing, an antigen presentation pathway in which DCs acquire and display intact tumor-derived peptide:MHC-I molecules, is also important in orchestrating anti-tumor immunity. Cancer cell MHC-I expression was required for optimal CD8⁺ T cell activation in two subcutaneous tumor models. In vivo acquisition of tumor-derived peptide:MHC-I molecules by DCs was sufficient to induce antigen-specific CD8⁺ T cell priming. Transfer of tumor-derived human leukocyte antigen (HLA) molecules to myeloi

SUBMITTER: MacNabb BW 

PROVIDER: S-EPMC9883788 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature