The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various cancers. However, its pattern in RCC remains poorly understood.

Results

We found that IL18 was significantly over-expressed in RCC tumor tissues compared to normal adjacent tissues The IL18 promoter region was hypomethylated, which was strongly correlated with elevated IL18 mRNA expression, and predicted advanced clinicopathological characteristics and shorter overall survival. Furthermore, we found that IL18 promoter methylation was significantly related to the down-regulation of immune ch

SUBMITTER: Wang X 

PROVIDER: S-EPMC9883904 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature