The optimal timing and intervention to reduce mortality for necrotizing pancreatitis: a systematic review and network meta-analysis.

ABSTRACT:

Background

A series of randomized controlled trials have investigated the efficacy and safety of different timings of interventions and methods of intervention. However, the optimal treatment strategy is not yet clear.

Methods

We searched PubMed, EMBASE, ClinicalTrials.gov and the Cochrane Library until November 30, 2022. A systematic review and Bayesian network meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Trials comparing different treatment strategies for necrotizing pancreatitis were included. This study was registered in the Prospective Register of Systematic Reviews (CRD42022364409) to ensure transparency.

Results

We analyzed a total of 10 studies involving 570 patients and 8 tr

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9883927 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature