Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma.

ABSTRACT:

Background

Metaplastic breast carcinoma (MpBC) typically consists of carcinoma of no special type (NST) with various metaplastic components. Although previous transcriptomic and proteomic studies have reported subtype-related heterogeneity, the intracase transcriptomic alterations between metaplastic components and paired NST components, which are critical for understanding the pathogenesis underlying the metaplastic processes, remain unclear.

Methods

Fifty-nine NST components and paired metaplastic components (spindle carcinomatous [SPS], matrix-producing, rhabdoid [RHA], and squamous carcinomatous [SQC] components) were microdissected from specimens obtained from 27 patients with MpBC for gene expression profiling using the NanoString Breast Cancer 360 Panel on a NanoStrin

SUBMITTER: Lien HC 

PROVIDER: S-EPMC9883935 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature