Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis.

ABSTRACT:

Background

Alzheimer's disease (AD) is an incurable neurodegenerative disorder characterised by the progressive buildup of toxic amyloid-beta (Aβ) and tau protein aggregates eventually leading to cognitive decline. Recent lines of evidence suggest that an impairment of the glymphatic system (GS), a brain waste clearance pathway, plays a key role in the pathology of AD. Moreover, a relationship between GS function and neuronal network integrity has been strongly implicated. Here, we sought to assess the efficacy of the GS in a transgenic Tet-Off APP mouse model of amyloidosis, in which the expression of mutant APP was delayed until maturity, mimicking features of late-onset AD-the most common form of dementia in humans.

Methods

To evaluate GS function, we used dynamic contras

SUBMITTER: Ben-Nejma IRH 

PROVIDER: S-EPMC9883946 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature