Extensively drug-resistant Acinetobacter baumannii: role of conjugative plasmids in transferring resistance.

ABSTRACT: Acinetobacter baumannii is one of the most successful pathogens that can cause difficult-to-treat nosocomial infections. Outbreaks and infections caused by multi-drug resistant A. baumannii are prevalent worldwide, with only a few antibiotics are currently available for treatments. Plasmids represent an ideal vehicle for acquiring and transferring resistance genes in A. baumannii. Five extensively drug-resistant A. baumannii clinical isolates from three major Jordanian hospitals were fully sequenced. Whole-Genome Sequences (WGS) were used to study the antimicrobial resistance and virulence genes, sequence types, and phylogenetic relationship of the isolates. Plasmids were characterized In-silico, followed by conjugation, and plasmid curing experiments. Ei

SUBMITTER: Ababneh Q 

PROVIDER: S-EPMC9884047 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature