Ontology highlight
ABSTRACT:
SUBMITTER: Cowan BS
PROVIDER: S-EPMC9884075 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Cowan Benjamin S BS Beveridge David L DL Thayer Kelly M KM
The journal of physical chemistry. B 20230110 3
Allosteric signaling in proteins has been known for some half a century, yet how the signal traverses the protein remains an active area of research. Recently, the importance of electrostatics to achieve long-range signaling has become increasingly appreciated. Our laboratory has been working on developing network approaches to capture such interactions. In this study, we turn our attention to the well-studied allosteric model protein, PDZ. We study the allosteric dynamics on a per-residue basis ...[more]