Critical windows of fluoride neurotoxicity in Canadian children.

ABSTRACT:

Background

Fluoride has been associated with IQ deficits during early brain development, but the period in which children are most sensitive is unknown.

Objective

We assessed effects of fluoride on IQ scores across prenatal and postnatal exposure windows.

Methods

We used repeated exposures from 596 mother-child pairs in the Maternal-Infant Research on Environmental Chemicals pregnancy and birth cohort. Fluoride was measured in urine (mg/L) collected from women during pregnancy and in their children between 1.9 and 4.4 years; urinary fluoride was adjusted for specific gravity. We estimated infant fluoride exposure (mg/day) using water fluoride concentration and duration of formula-feeding over the first year of life. Intelligence was assessed at 3-4 years using the Wec

SUBMITTER: Farmus L 

PROVIDER: S-EPMC9884092 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature