Telomerase structural biology comes of age.
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ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC9884118 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Telomerase structural biology comes of age.
Current opinion in structural biology 20220906
Telomerase is an RNA-protein complex comprising telomerase reverse transcriptase, a non-coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or recruitment. Telomerase synthesizes the telomeric DNA at the 3'-ends of linear chromosomes. During the past decade, structural studies have defined the architecture of Tetrahymena and human telomerase as well as protein and RNA domain structures, but high-resolution details of interactions remained largely elusive. In the p ...[more]
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