Ontology highlight
ABSTRACT:
SUBMITTER: Mondal P
PROVIDER: S-EPMC9884120 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Mondal Pinaki P Patel Neesha S NS Bailey Katie K Aravind Shruthishree S Cartwright Sara B SB Hollingsworth Michael A MA Lazenby Audrey J AJ Carlson Mark A MA
Disease models & mechanisms 20230116 1
The 5-year survival of pancreatic cancer (PC) remains low. Murine models may not adequately mimic human PC and can be too small for medical device development. A large-animal PC model could address these issues. We induced and characterized pancreatic tumors in Oncopigs (transgenic swine containing KRASG12D and TP53R167H). The oncopigs underwent injection of adenovirus expressing Cre recombinase (AdCre) into one of the main pancreatic ducts. Resultant tumors were characterized by histology, cyto ...[more]