Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study.

ABSTRACT: Organophosphate esters (OPEs) are developmental toxicants in experimental studies of animals, but limited evidence is available in humans. We included 340 mother-infant pairs in the Health Outcomes and Measures of the Environment (HOME) Study (Cincinnati, Ohio, USA) for the analysis. We evaluated gestational exposure to OPEs with gestation age at birth and newborn anthropometric measures. We quantified four OPE urinary metabolites at 16 weeks and 26 weeks of gestation. We extracted gestational age at birth, newborn weight, length, and head circumference from the chart review. We calculated z-scores for these anthropometric measures and the ponderal index. We used multiple informant models to examine the associations between repeated OPE measurements and the outcomes. We used modified Poiss

SUBMITTER: Yang W 

PROVIDER: S-EPMC9884151 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature