Usefulness of pyruvate dehydrogenase-E1α expression to determine SUVmax cut-off value of [¹⁸F]FDG-PET for predicting lymph node metastasis in lung cancer.

ABSTRACT: A more accurate cut-off value of maximum standardized uptake value (SUVmax) in [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG-PET/CT) is necessary to improve preoperative nodal staging in patients with lung cancer. Overall, 223 patients with lung cancer who had undergone [¹⁸F]FDG-PET/CT within 2 months before surgery were enrolled. The expression of glucose transporter-1, pyruvate kinase-M2, pyruvate dehydrogenase-E1α (PDH-E1α), and carbonic anhydrase-9 was evaluated by immunohistochemistry. Clinicopathological background was retrospectively investigated. According to PDH-E1α expression in primary lesion, a significant difference (p = 0.021) in SUVmax of metastatic lymph nodes (3.0 with PDH-positive vs 4.5 with PDH-negati

SUBMITTER: Ito R 

PROVIDER: S-EPMC9884208 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature