Dataset Information

Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K⁺ Channels and Human ether-a-go-go-Related Gene Channels.

ABSTRACT: Most blockers of both hERG (human ether-à-go-go-related gene) channels and pancreatic ß-cell ATP-sensitive K⁺ (K_ATP) channels access their binding sites from the cytoplasmic side of the plasma membrane. It is unknown whether binding to intracellular components competes with binding of these substances to K⁺ channels. The whole-cell configuration of the patch-clamp technique, a laser-scanning confocal microscope, and fluorescence correlation spectroscopy (FCS) were used to study hERG channels expressed in HEK (human embryonic kidney) 293 cells and K_ATP channels from the clonal insulinoma cell line RINm5F. When applied via the pipette solution in the whole-cell configuration, terfenadine blocked both hERG and K_ATP currents with much lowe

SUBMITTER: Zunkler BJ

PROVIDER: S-EPMC9884252 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Dataset Information

Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K⁺ Channels and Human ether-a-go-go-Related Gene Channels.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-a-go-go-Related Gene Channels.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K⁺ Channels and Human ether-a-go-go-Related Gene Channels.