Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.

ABSTRACT: A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousness into distributed patterns of structure-function dependence across scales: the harmonic modes of the human structural connectome. We show that structure-function coupling is a generalisable indicator of consciousness that is under bi-directional neuromodulatory control. We find increased structure-function coupling across scales during loss of consciousness, whether due to anaesthesia or brain injury, capable of discriminating between behaviourally indistinguishable sub-categories of brain-injured patients, tracking the presence of covert consciousness

SUBMITTER: Luppi AI 

PROVIDER: S-EPMC9884288 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature