Recurrent Glioblastoma: Ongoing Clinical Challenges and Future Prospects.

ABSTRACT: Virtually all glioblastomas treated in the first-line setting will recur in a short period of time, and the search for alternative effective treatments has so far been unsuccessful. Various obstacles remain unresolved, and no effective salvage therapy for recurrent glioblastoma can be envisaged in the short term. One of the main impediments to progress is the low incidence of the disease itself in comparison with other pathologies, which will be made even lower by the recent WHO classification of gliomas, which includes molecular alterations. This new classification helps refine patient prognosis but does not clarify the most appropriate treatment. Other impediments are related to clinical trials: glioblastoma patients are often excluded from trials due to their advanced age and limiting n

SUBMITTER: Pineda E 

PROVIDER: S-EPMC9884437 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature