Precision oncology using ex vivo technology: a step towards individualised cancer care?

ABSTRACT: Despite advances in cancer genomics and the increased use of genomic medicine, metastatic cancer is still mostly an incurable and fatal disease. With diminishing returns from traditional drug discovery strategies, and high clinical failure rates, more emphasis is being placed on alternative drug discovery platforms, such as ex vivo approaches. Ex vivo approaches aim to embed biological relevance and inter-patient variability at an earlier stage of drug discovery, and to offer more precise treatment stratification for patients. However, these techniques also have a high potential to offer personalised therapies to patients, complementing and enhancing genomic medicine. Although an array of approaches are available to researchers, only a minority of techniques have made it through to direct

SUBMITTER: Williams ST 

PROVIDER: S-EPMC9884776 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature