Genomic insights of mcr-1 harboring Escherichia coli by geographical region and a One-Health perspective.

ABSTRACT: The importance of the One Health concept in attempting to deal with the increasing levels of multidrug-resistant bacteria in both human and animal health is a challenge for the scientific community, policymakers, and the industry. The discovery of the plasmid-borne mobile colistin resistance (mcr) in 2015 poses a significant threat because of the ability of these plasmids to move between different bacterial species through horizontal gene transfer. In light of these findings, the World Health Organization (WHO) recommends that countries implement surveillance strategies to detect the presence of plasmid-mediated colistin-resistant microorganisms and take suitable measures to control and prevent their dissemination. Seven years later, ten different variants of the mcr gene (

SUBMITTER: Calero-Caceres W 

PROVIDER: S-EPMC9884825 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature