Decreased capsaicin cough reflex sensitivity predicts hospitalisation due to COPD.

ABSTRACT:

Introduction

Patients with chronic obstructive pulmonary disease (COPD) are often hospitalised due to severe acute exacerbation (AE) or community-acquired pneumonia (CAP). Previous studies revealed the association of cough reflex sensitivity with the pathophysiology of COPD and pneumonia. We hypothesised that cough reflex sensitivity may be associated with severe AE or CAP requiring hospitalisation in patients with COPD.

Methods

We prospectively recruited 68 patients with COPD between June 2018 and January 2020. Patient characteristics, lung and cardiac functions, and biomarkers, including capsaicin cough reflex sensitivity and blood eosinophil count, were evaluated at enrolment. All participants were monitored for AE or CAP requiring hospitalisation for 12 months. We determ

SUBMITTER: Kanemitsu Y 

PROVIDER: S-EPMC9884861 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature