Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study.

ABSTRACT:

Background

Population distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.

Methods

A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determinatio

SUBMITTER: Garcia-Rio F 

PROVIDER: S-EPMC9884864 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature