Effects of the July 2018 worldwide valsartan recall and shortage on global trends in antihypertensive medication use: a time-series analysis in 83 countries.

ABSTRACT:

Objectives

This study aims to examine the effects of the July 2018 worldwide valsartan recall and shortage on global trends of antihypertensive medication use in 83 countries.

Methods

A time-series analysis of monthly purchases of valsartan, other angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) across 83 countries from January 2017 to July 2020 was conducted using the IQVIA MIDAS database. Trends in outcomes were investigated globally and by economic level (developed vs developing economies). The valsartan recall's impact on antihypertensive use was assessed with interventional autoregressive integrated moving average modelling.

Results

Global valsartan utilisation trends decreased significantly by 15.7% (-61 166 515 SU; p<

SUBMITTER: Choi Y 

PROVIDER: S-EPMC9884936 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature