Identification of lymph node metastasis-related genes and patterns of immune infiltration in colon adenocarcinoma.

ABSTRACT:

Backgrounds

Colon adenocarcinoma(COAD) is one of the most common tumors of the digestive tract. Lymph node metastasis (LNM) is a well-established prognostic factor for COAD. The mechanism of COAD lymph node metastasis in immunology remains unknown. The identification of LNM-related biomarkers of COAD could help in its treatment. Thus, the current study was aimed to identify key genes and construct a prognostic signature.

Methods

Gene expression and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes were calculated by using R software. GO functional and KEGG pathway enrichment analysis were processed. The CIBERSORT algorithm was used to assess immune cell infiltration. STRING database was used to screen key genes and const

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9884978 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature