The potential of using circulating tumour cells and their gene expression to predict docetaxel response in metastatic prostate cancer.

ABSTRACT:

Background

Docetaxel improves overall survival (OS) in castration-resistant prostate cancer (PCa) (CRPC) and metastatic hormone-sensitive PCa (mHSPC). However, not all patients respond due to inherent and/or acquired resistance. There remains an unmet clinical need for a robust predictive test to stratify patients for treatment. Liquid biopsy of circulating tumour cell (CTCs) is minimally invasive, can provide real-time information of the heterogeneous tumour and therefore may be a potentially ideal docetaxel response prediction biomarker.

Objective

In this study we investigate the potential of using CTCs and their gene expression to predict post-docetaxel tumour response, OS and progression free survival (PFS).

Methods

Peripheral blood was sampled from 18 mCRPC and 4

SUBMITTER: Davies CR 

PROVIDER: S-EPMC9885040 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature