Aldosterone defects in infants and young children with hyperkalemia: A single center retrospective study.

ABSTRACT:

Introduction

Hyperkalemia is a rare but severe condition in young children and usually discovered as a result of hemolysis of the blood samples taken. However, patients with defects in either aldosterone biosynthesis or function can also present with hyperkalemia- as well hyponatremia-associated, and metabolic acidosis. It is a challenge to make an accurate diagnosis of these clinical conditions. We conducted this study to investigate the clinical and genetic features of aldosterone signaling defects associated hyperkalemia in young children.

Method

A retrospective review was conducted at the pediatric department of the First Affiliated Hospital of Guangxi Medical University from 2012 to 2022.

Results

47 patients with hyperkalemia were enrolled, of which 80.9% (n</

SUBMITTER: Liu X 

PROVIDER: S-EPMC9885047 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature