A four-microRNA panel in serum may serve as potential biomarker for renal cell carcinoma diagnosis.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is one out of the most universal malignant tumors globally, and its incidence is increasing annually. MicroRNA (miRNA) in serum could be considered as a non-invasive detecting biomarker for RCC diagnosis.

Method

A total of 224 participants (112 RCC patients (RCCs) and 112 normal controls (NCs)) were enrolled in the three-phrase study. Reverse transcription quantitative PCR (RT-qPCR) was applied to reveal the miRNA expression levels in RCCs and NCs. Receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC) were utilized to predict the diagnostic ability of serum miRNAs for RCC. Bioinformatic analysis and survival analysis were also included in our study.

Results

Compared to NCs, the expression degree of

SUBMITTER: Li R 

PROVIDER: S-EPMC9885090 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature