Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis.

ABSTRACT: Mitochondria are maternally inherited organelles that play critical tissue-specific roles, including hormone synthesis and energy production, that influence human development, health, and aging. However, whether mitochondria from women and men exhibit consistent biological differences remains unclear, representing a major gap in knowledge. This meta-analysis systematically examined four domains and six subdomains of mitochondrial biology (total 39 measures), including mitochondrial content, respiratory capacity, reactive oxygen species (ROS) production, morphometry, and mitochondrial DNA copy number. Standardized effect sizes (Hedge's g) of sex differences were computed for each measure using data in 2258 participants (51.5% women) from 50 studies. Only two measures demonstrated aggregate

SUBMITTER: Junker A 

PROVIDER: S-EPMC9885138 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature