Positive regulators of T cell functions as predictors of prognosis and microenvironment characteristics of low-grade gliomas.

ABSTRACT:

Background

Low-grade gliomas (LGG) are one of the most prevalent types of brain cancers. The efficacy of immunotherapy in LGG is limited compared to other cancers. Immunosuppression in the tumor microenvironment (TME) of LGG is one of the main reasons for the low efficacy of immunotherapy. Recent studies have identified 33 positive regulators of T cell functions (TPRs) that play a critical role in promoting the proliferation, activity, and functions of multiple immunocytes. However, their role in the TME of LGG has not been investigated. This study aimed to construct a risk model based on these TPRs and to detect the significance of immunotypes in predicting LGG prognosis and immunotherapy efficacy.

Methods

A total of 688 LGGs and 202 normal brain tissues were extracted from

SUBMITTER: Li Y 

PROVIDER: S-EPMC9885161 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature