Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guerin (BCG) inoculated macaques.

ABSTRACT:

Background

Although BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined correlates of protection in TB disease, it is essential to explore immune responses beyond conventional CD4 T cells to gain a better understanding of the mechanisms of TB immunity.

Methods

Here, we evaluated unconventional lipid-reactive T cell responses in cynomolgus macaques following aerosol BCG inoculation and examined the impact of subsequent SIV infection on these responses. Immune responses to cellular lipids of M. bovis and M. tuberculosis were examined ex vivo in peripheral blood and bronchioalveolar lavage (BAL).

Resu

SUBMITTER: Walker EM 

PROVIDER: S-EPMC9885173 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature