Identification and validation of a novel angiogenesis-related gene signature for predicting prognosis in gastric adenocarcinoma.

ABSTRACT:

Background

Angiogenesis is a major promotor of tumor progression and metastasis in gastric adenocarcinoma (STAD). We aimed to develop a novel lncRNA gene signature by identifying angiogenesis-related genes to better predict prognosis in STAD patients.

Methods

The expression profiles of angiogenesis-related mRNA and lncRNA genes were collected from The Cancer Genome Atlas (TCGA). Then, the "limma" package was used to identify differentially expressed genes (DEGs). The expression profiles of angiogenesis-related genes were clustered by consumusclusterplus. The Pearson correlation coefficient was further used to identify lncRNAs coexpressed with angiogenesis-related clustere genes. We used Lasso Cox regression analysis to construct the angiogenesis-related lncRNAs signature. Fu

SUBMITTER: Xu P 

PROVIDER: S-EPMC9885177 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature