Association between antipsychotic medication and clinically relevant weight change: meta-analysis.

ABSTRACT:

Background

Previous meta-analyses have shown that almost all antipsychotics are associated with weight gain. However, mean weight gain is not informative about clinically relevant weight gain or weight loss.

Aims

To provide further insight into the more severe body weight changes associated with antipsychotic use, we assessed the proportion of patients with clinically relevant weight gain (CRWG) and clinically relevant weight loss (CRWL), defined as ≥7% weight gain and ≥7% weight loss.

Method

We searched PubMed, Embase and PsycInfo for randomised controlled trials of antipsychotics that reported CRWG and CRWL in study populations aged 15 years or older. We conducted meta-analyses stratified by antipsychotic and study duration using a random-effects model. We performed

SUBMITTER: Campforts B 

PROVIDER: S-EPMC9885350 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature