Potent hepatoprotective activity of common rattan (Calamus rotang L.) leaf extract and its molecular mechanism.

ABSTRACT:

Background

Calamus rotang L. (CR) is an Indian shrub. The leaves and other organs of the plant are traditionally used in India for treatment of various diseases. The in vitro antioxidant property of the leaves extract was previously established. Thus, the current study aimed to evaluate the antioxidant and hepatoprotective effects of CR ethyl acetate extract at a dose of 350 mg/kg on CCl₄ induced hepatotoxic rats through different mechanisms.

Methods

Histopathological examination of the treated rats' group in comparison with positive and negative controls were performed. Quantitative measuring of the proinflammatory cytokines (TNF α), inflammatory regulators (Arginase, PPAR α) and the antiapoptotic protein Bcl-2 in comparison with positive and negative control gro

SUBMITTER: Anwar WS 

PROVIDER: S-EPMC9885597 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature