Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway.

ABSTRACT:

Objective

Previous studies have revealed associations between hyperuricemia and microvascular diseases, but the association between hyperuricemia and abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to elucidate the pathogenesis and prove the relationship between AAA and hyperuricemia.

Methods

A retrospective study was performed to validate the growth rates of AAA in humans with different serum uric acid levels. A murine model of angiotensin II-induced AAA was used to assess the effects of hyperuricemia on AAA growth in vivo, and human aortic smooth muscle cells (HASMCs) were used to study the pathways involved in these effects in vitro.

Results

We analyzed data from 107 AAA patients and found that patients with serum uric acid levels above 9

SUBMITTER: Wang JC 

PROVIDER: S-EPMC9885634 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature