Genetic association and causal inference between lung function and venous thromboembolism.

ABSTRACT:

Background

Previous studies have indicated that lower lung function is related to a higher risk of venous thromboembolism (VTE). However, causal inferences may be affected by confounders, coheritability or reverse causality. We aimed to explore the causal association between lung function and VTE.

Methods

Summary data from public genome-wide association studies (GWAS) for lung function and VTE were obtained from published meta-analysis studies and the FinnGen consortium, respectively. Independent genetic variables significantly related to exposure were filtered as proxy instruments. We adopted linkage disequilibrium score regression (LDSC) and two-sample Mendelian randomization (MR) analyses to infer the genetic backgrounds and causal associations between different lung func

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9885683 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature