Dataset Information

Clinical Profile of Parathyroid Adenoma in Children and Adolescents: A Single-Center Experience.

ABSTRACT:

Objective

Parathyroid adenoma is less common than in adulthood, but its morbidity is higher in children. We aimed to evaluate the clinical characteristics of parathyroid adenoma and our clinical experience since the early disease is often asymptomatic and late diagnosed.

Materials and methods

From 2010 to 2020, all children diagnosed with parathyroid adenoma at our institution were reviewed. We evaluated clinical, biochemical, and radiological aspects and follow-up characteristics.

Results

Eight subjects (F/M = 6/2) ranged in age from 10 to 17 years. Three were symptomatic. The symptoms and findings were stomachache (n = 3), myalgia (n = 2), weakness (n = 2), pancreatitis (n = 1), constipation (n = 1), nausea (n = 1), bone ache (n = 1), and anorexia (n = 1). Laboratory findings on admission were as follows: the mean calcium was 12.59 ± 1.28 (11.2-15.3) mg/dL and the mean parathyroid hormone was 244.81 ± 173.61 (74.9-645.4) pg/mL. The most common localization was the lower part of the left parathyroid gland. Parathyroid adenoma could not be demonstrated by ultrasonography in 2 patients. Tc-99m-Sestamibi scintigraphy revealed the presence of parathyroid adenoma in only 7 of 8 patients. All underwent parathyroidectomy. In our follow-up, 2 subjects needed reoperation. A molecular analysis of 6 cases could be done. One was MEN1 positive. RET sequence analysis of 2, and Casr, GNA11, and AP2S1 sequence analysis of 3 were normal.

Conclusion

Parathyroid adenoma should be considered in children older than the first decade with hypercalcemia. Suspected cases should undergo both ultrasonography and scintigraphy. Early diagnosis prevents the patients from serious complications of hypercalcemia such as nephrocalcinosis, diabetes insipid, and arrhythmia. It is significant to perform surgery in centers experienced in parathyroidectomy to minimize postoperative complications.

SUBMITTER: Kızılcan Cetin S

PROVIDER: S-EPMC9885779 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Clinical Profile of Parathyroid Adenoma in Children and Adolescents: A Single-Center Experience.

Kızılcan Çetin Sirmen S Şıklar Zeynep Z Aycan Zehra Z Özsu Elif E Ceran Ayşegül A Erisen Karaca Seda S Senyazar Gizem G Berberoğlu Merih M

Turkish archives of pediatrics 20230101 1

<h4>Objective</h4>Parathyroid adenoma is less common than in adulthood, but its morbidity is higher in children. We aimed to evaluate the clinical characteristics of parathyroid adenoma and our clinical experience since the early disease is often asymptomatic and late diagnosed.<h4>Materials and methods</h4>From 2010 to 2020, all children diagnosed with parathyroid adenoma at our institution were reviewed. We evaluated clinical, biochemical, and radiological aspects and follow-up characteristics ...[more]

PMID: 36598212

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Dataset Information

Clinical Profile of Parathyroid Adenoma in Children and Adolescents: A Single-Center Experience.

Objective

Materials and methods

Results

Conclusion

Publications

Clinical Profile of Parathyroid Adenoma in Children and Adolescents: A Single-Center Experience.

Similar Datasets

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