IgG4+ cells are increased in the gastrointestinal tissue of pediatric patients with active eosinophilic gastritis and duodenitis and decrease in remission.

ABSTRACT:

Background

Recent studies have shown that IgG4 is increased in the esophageal tissue of eosinophilic esophagitis patients, including the presence of IgG4+ plasma cells.

Aims

Our aim was to determine whether IgG4 is elevated in the gastric or duodenal tissue of pediatric patients with eosinophilic gastritis or duodenitis (EoG or EoD).

Methods

This was a retrospective single center study. Pediatric patients were characterized as having active EoG, EoD, or as controls based on clinical symptoms and histologic features. Immunohistochemistry for IgG4 was performed in gastric and duodenal tissue, and peak IgG4+ cells were compared between groups and after treatment.

Results

The frequency of IgG4+ cells was significantly higher in patients with EoG and EoD compared to

SUBMITTER: Quinn L 

PROVIDER: S-EPMC9885790 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature