Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma.

ABSTRACT:

Background

Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the development of asthma. The purpose of this study is to identify novel genetic susceptibility loci for asthma in Taiwanese. We selected a well-studied long non-coding RNA (lncRNA), MEG3, which is involved in multiple cellular functions and whose expression has been associated with asthma. We hypothesize that genetic variants in MEG3 may influence the risk of asthma.

Methods

We genotyped four single nucleotide polymorphisms (SNPs) in MEG3, rs7158663, rs3087918, rs11160608, and rs4081134, in 198 patients with asthma

SUBMITTER: Chiu KL 

PROVIDER: S-EPMC9885862 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature