Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne.

ABSTRACT: Innate immune defense against deep tissue infection by Staphylococcus aureus is orchestrated by fibroblasts that become antimicrobial when triggered to differentiate into adipocytes. However, the role of this process in noninfectious human diseases is unknown. To investigate the potential role of adipogenesis by dermal fibroblasts in acne, a disorder triggered by Cutibacterium acnes, single-cell RNA sequencing was performed on human acne lesions and mouse skin challenged by C. acnes. A transcriptome consistent with adipogenesis was observed within specific fibroblast subsets from human acne and mouse skin lesions infected with C. acnes. Perifollicular dermal preadipocytes in human acne and mouse skin lesions showed colocalization of PREF1, an early marker of adi

SUBMITTER: O'Neill AM 

PROVIDER: S-EPMC9885891 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature