Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications.

ABSTRACT: Hypertension is a major cardiovascular disease risk factor and contributor to premature death globally. Family-based investigations confirmed a significant heritable component of blood pressure (BP), whereas genome-wide association studies revealed >1000 common and rare genetic variants associated with BP and/or hypertension. The kidney is not only an organ of key relevance to BP regulation and the development of hypertension, but it also acts as the tissue mediator of genetic predisposition to hypertension. The identity of kidney genes, pathways, and related mechanisms underlying the genetic associations with BP has started to emerge through integration of genomics with kidney transcriptomics, epigenomics, and other omics as well as through applications of causal inference, such as Mendel

SUBMITTER: Tomaszewski M 

PROVIDER: S-EPMC9886011 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature