Different meaning of the mean heart dose between 3D-CRT and IMRT for breast cancer radiotherapy.

ABSTRACT:

Background

Previous studies in 2D and in 3D conformal radiotherapy concludes that the maximal heart distance and the mean heart dose (MHD) are considered predictive of late cardiac toxicities. As the use of inverse-planned intensity modulated radiation therapy (IMRT) is increasing worldwide, we hypothesized that this 3D MHD might not be representative of heart exposure after IMRT for breast cancer (BC).

Methods

Patients with left-sided BC and unfavorable cardiac anatomy received IMRT. Their treatment plan was compared to a virtual treatment plan for 3D conformal radiotherapy with similar target volume coverage (study A). Then, a second 3D conformal treatment plan was generated to achieve equivalent individual MHD obtained by IMRT. Then the heart and left anterior descending

SUBMITTER: Prunaretty J 

PROVIDER: S-EPMC9886087 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature