B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV.

ABSTRACT:

Background

Limited longitudinal data are available on immune response to mRNA SARS-CoV-2 vaccination in people living with HIV (PLWHIV); therefore, new evidence on induction and persistence of spike-specific antibodies and B cells is needed.

Methods

In this pilot study we investigated the spike-specific humoral and B cell responses up to six months after vaccination with two doses of mRNA vaccines in 84 PLWHIV under antiretroviral therapy compared to 79 healthy controls (HCs).

Results

Spike-specific IgG persisted six months in PLWHIV with no significant differences compared to HCs, even though a significantly lower IgG response was observed in patients with CD4⁺ T cells < 350/mmc. The frequency of subjects with antibodies capable of inhibiting ACE2/RBD bind

SUBMITTER: Polvere J 

PROVIDER: S-EPMC9886211 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature