Causal associations of anthropometric measurements with osteoarthritis: A Mendelian randomization study.

ABSTRACT:

Objective

We believe that there is a causal relationship between waist circumference and knee osteoarthritis. To confirm the hypothesis, we have conducted this study.

Methods

Genetic variants associated with the five anthropometric variables were obtained from previous large-scale genomewide association studies. Summary-level data on osteoarthritis were obtained from the UK Biobank. The univariable and multivariable MR framework were used to evaluate the associations. The two-sided p value was considered to be statistically significant at 0.01 (where p = 0.05/5) after Bonferroni correction for the five exposure variables.

Results

In the univariable MR, there was evidence of a detrimental effect of height, weight, BMI, waist circumference, and hip circumference on oste

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9886244 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature