Do correlates of white matter features differ between older men and women living with human immunodeficiency virus?

ABSTRACT:

Objective

Given estrogen's role in human immunodeficiency virus (HIV) disease progression and the higher rates of neurocognitive decline in affected women, the purpose of this study was to assess whether the relationship of white matter features and reproductive hormone levels differed between men versus women (sex as a moderator), controlling for selected cardiometabolic risk factors, HIV-related health indicators, and demographics in an aging population of persons living with HIV (PLWH).

Methods

Older PLWH (50 y and older; 44 women and 35 men; mean ± SD age, 59.8 ± 0.6 y; 55.7% women; 72.2% non-Hispanic Black) participated in a cross-sectional study involving a fasting blood draw and a demographic survey (visit 1) and a magnetic resonance imaging scan (visit 2) to determin

SUBMITTER: Gordian-Arroyo A 

PROVIDER: S-EPMC9886314 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature