Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence.

ABSTRACT:

Background

Early-onset depression during childhood and adolescence is associated with a worse course of illness and outcome than adult onset. However, the genetic factors that influence risk for early-onset depression remain mostly unknown. Using data collected over 13 years, we examined whether polygenic risk scores (PRS) that capture genetic risk for depression were associated with depressive symptom trajectories assessed from childhood to adolescence.

Methods

Data came from the Avon Longitudinal Study of Parents and Children, a prospective, longitudinal birth cohort (analytic sample = 7,308 youth). We analyzed the relationship between genetic susceptibility to depression and three time-dependent measures of depressive symptoms trajectories spanning 4-16.5 years of age (cl

SUBMITTER: Lussier AA 

PROVIDER: S-EPMC9886425 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature