Protein Acetylation Increased Risk of Fibrosis-Related Liver Cancer.

ABSTRACT:

Objective

The occurrence of liver fibrosis and fibrosis-related liver cancer is the reason for the increase in morbidity and mortality worldwide. Transforming growth factor-β2 (TGF-β2) is an important mediator of chronic liver fibrosis. This study aims to find the molecular mechanism that mediates HBV infection and induces TGF-β2 and verifies that CREB binding protein acetylation mediates HBV infection and induces TGF-β2 expression.

Methods

The acetylated proteins were extracted from HepG2-NTCP cells and HBV-infectedHepG2-NTCP cells. The acetylated proteins were screened by modification enrichment technology and database search. Protein annotation, motif analysis of modification sites, and protein function enrichment analysis of these proteins wer

SUBMITTER: Li Y 

PROVIDER: S-EPMC9886473 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature