The Effective Components, Core Targets, and Key Pathways of Ginseng against Alzheimer's Disease.

ABSTRACT:

Background

Panax ginseng C. A. Mey (ginseng) is a traditional Chinese medicinal herb used for the treatment of nervous system disorders, such as Alzheimer's disease (AD). However, the pharmacological mechanisms of ginseng involved in AD have not been systematically investigated. Here, a network pharmacology approach was adopted to explore the effective components, core targets, and key pathways of ginseng against AD.

Methods

TCMSP database was used to screen the active ingredients of ginseng. Prediction of the targets of ginseng and AD-related genes was performed using online public databases. "Compound-Target," "Compound-Target-Disease," "Protein-Protein Interaction (PPI)," "Compound-Target-Pathway," and "Compound-Target-GO-Pathway" networ

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9886485 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature